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KMID : 1134220070270030028
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Hanyang Medical Reviews
2007 Volume.27 No. 3 p.28 ~ p.33
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Virulence factors of Helicobacter pylori and their clinical significances
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Lee Yong-Chan
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Abstract
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Helicobacter pylori (H. pylori) is known be an etiologic factor for gastric and duodenal ulcer, gastric noncardiac adenocarcinoma, and MALT lymphoma in a subset of infected individuals. Pathogenesis of H. pylori infection is based on the long term host to bacterial interaction and may be affected by various virulence factors of the bacterium,
environmental, and host factors (age, sex, blood type). Mucosal inflammation is the basic principle mechanism underlying the disease development in which tissue destruction may be initiated and maintained by both the bacterial toxins (cagA, vacA) and host immune responses. Immune evasion by bacterial modulation of host response affects the long term colonization of the microbe. Colonization is also affected by urease and/or motility of the bacterium, lipopolysaccharide, and others. Investigation into the pathogenesis of H. pylori related diseases based on bacterial
virulence factors could provide answer to the impact of chronic host to microbial interaction resulting in human diseases.
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KEYWORD
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Helicobacter pylori, Pathogenesis, Virulence factors
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